Abstract
A spin state-selective Heteronuclear Single-Quantum Multiple-Bond Connectivities (HSQMBC-COSY) experiment is proposed to measure the sign and the magnitude of long-range proton-carbon coupling constants ((n)J(CH); n > 1) either for protonated or for non-protonated carbons in small molecules. The simple substitution of the selective 180° (1)H pulse in the original selHSQMBC pulse scheme by a hard one allows the simultaneous evolution of both proton-proton and proton-carbon coupling constants during the refocusing period and enables a final COSY transfer between coupled protons. The successful implementation of the IPAP principle leads to separate mixed-phase α/β cross-peaks from which (n)J(CH) values can be easily measured by analyzing their relative frequency displacements in the detected dimension.
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