Efficient Green Chemistry Approach for the Synthesis of 1,2,3-Triazoles Using Click Chemistry through Cycloaddition Reaction: Synthesis and Cytotoxic Study

Abstract

Herein, we reported the synthesis of diverse N-(substituted phenyl)-2-(4-((dibenzylamino)methyl)-1H-1,2,3-triazol-1-yl)acetamide (6a–6j) through a green chemistry approach using water and eco-friendly catalysts using copper catalyzed click chemistry approach. The optimization of the reaction toward the greener way was discussed through applying the choline azide and ecological suitable solvent/reagent systems. The biological potency of the adducts was described against NCI-60 cancer cell lines in nine cancer panels and four scaffolds with halogens as phenyl ring substituents were found to be most active with negative GI50 values. Supplemental data for this article is available online at