Abstract
In this paper, the potential application of bis(trifluoromethylsulfonyl)imide based ionic liquids paired with various cations (ammonium, piperidinium, pyridinium and imidazolium) as the recyclable reaction media for the esterification of curcumin has been investigated. The results showed that it is possible to obtain the product of curcumin diacetate (DAC) at moderate conditions and exclude the use of organic solvents, which is a high improvement in comparison to the known methods for prodrugs intermediates synthesis. In addition, the mechanism and kinetics of the esterification reaction have been studied. The presence of IL allows to reach the chemical equilibrium more rapidly, they also increase the reaction rate of the process.
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