Abstract
Investigations of calcium-phosphate-metabolism should be initiated in children displaying conspicuous clinical or radiological symptoms and/or isolated or combined abnormalities of calcium phosphate and alkaline phosphatase in serum. In most cases the investigation of a child with a suspected disorder of mineral metabolism is rapidly and efficiently performed by simultaneous measurements of some indices of calcium metabolism in serum and fasting early morning urine specimens. This is emphazised by presenting a laboratory approach to the differential diagnosis in hypocalcemic and hypercalcemic patients.
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