Abstract
A series of isolated or preformed in-situ aliphatic PNP-type pincer ruthenium complexes have been evaluated for deuterium labelling of alcohols' C-H functions with deuterium oxide. Under our catalytic conditions, pincer-supported ruthenium complexes bearing cyclohexyl substituents on the phosphorous atoms have been found to be the most efficient and regioselective catalysts for α-deuteration of primary alcohols, affording up to 94% of α-C-H deuteration with only 5% of β-C-H deuteration in the case of n-butanol.
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