Abstract
The main aim of present study is to develop the nanocrystals as a viable drug delivery strategy for the improvement of dissolution rate and bioavailability of dexibuprofen. Dexibuprofen nanocrystals were prepared by the combination of precipitation and high shear homogenization method. Particle size and morphology of produced nanocrystals were compared with that of the pure drug. Particle size of nanocrystals is in the range of 95 to 117 nm were as 2.43µm for pure drug. Photomicrographs of phase contrast microscopy and the TEM showed the spherical shape of the nanocrystals. In-vitro drug release of dexibuprofen nanocrystals formulations was studied by dialysis bag method and observed the drug release of 92 to 100% within 6 hrs. Hence we conclude that the formulated nanocrystals may offer exciting opportunities for oral and other formulations.
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