Abstract
The direct aroylation of ArCOPdCl with potassium aryltrifluoroborates establishes a new cross-coupling synthetic tool for the synthesis of various fluorine substituted benzophenones. The new microwave irradiated process is very efficient and produce high yield benzophenone products within minutes.
Highlights
This work demonstrates the novel application of potassium aryltrifluoroborates with aroyl chlorides for cross coupling reaction
Experimental Synthesis of aryl trifluoroborates (BF3K); the starting material ArBF3K is synthesized from boronic acid
In a round bottom flask with a stirrer, about 20 mL of methanol was added to 20 mmol of boronic acid
Summary
The direct aroylation of ArCOPdCl with potassium aryltrifluoroborates establishes a new cross-coupling synthetic tool for the synthesis of various fluorine substituted benzophenones. The new microwave irradiated process is very efficient and produce high yield benzophenone products within minutes. ArBF3K, Aroyl Chlorides, Direct Aroylation to Ketones, Minute Reaction
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