Efficient anticarcinogenic activity of α-Fe2O3 nanoparticles: In-vitro and computational study on human renal carcinoma cells HEK-293

Abstract

The present study has witnessed the synthesis of α-Fe2O3 NPs using polyethylene glycol (PEG) as a surfactant and l-ascorbic acid (LAA) as a stabilizer. The product has been characterized by UV–vis absorption spectroscopy, FTIR, Dynamic Light Scattering, particle size distribution analysis, X-ray diffraction analysis, TEM, FESEM, EDX and BET, which show formation of variable size and shape, mesoporous, PEG-coated α-Fe2O3 NPs (LAA@IONP-PEG) with β-FeOOH as an impurity. The present work emphasizes upon an anti-cancer study of LAA@IONP-PEG against renal carcinoma HEK-293 human embryonic kidney cell lines. The study suggests that LAA@IONP-PEG is a promising material against renal carcinoma HEK-293 human embryonic kidney cell lines. The docking study has confirmed anti-proliferative action of NPs through binding affinity with renal carcinoma molecular targets. The synthesized NPs show the synergistic effect with Axitinib as an anti-cancer drug effective against renal carcinoma cell lines. ROS and 1,1-diphenyl-2-picrylhydrazine (DPPH) free radical scavenging assay have shown the antioxidant capability of synthesized NPs. The efficient biocatalytic activity of LAA@IONP-PEG prescribes its use as one of the best suited drugs for the future perspectives against fatal renal carcinoma and thus it is reckoned that synthesized NPs will have persistent utilization in different field of medical applications.