Efficient and Sustainable Synthesis of Spiroannulated Hybrid Molecules with Privileged Substructures using Nanostructured Heterogeneous Catalyst

Abstract

AbstractSpiroannulated hybrid molecules with privileged substructures have been synthesized by an efficient and sustainable synthetic protocol involving isocyanide‐based four component reaction of benzene‐1,2‐diamine, 2‐hydroxynaphthalene‐1,4‐dione, cyclic ketones and isocyanides catalyzed by recyclable and reusable nanostructured TiO2 with Erbium(Er) doping as heterogeneous catalyst. The synthetic protocol with special features, that is, atom and step economy, operational simplicity, synthetic efficiency and superior catalytic activity with sustainability and its recyclability and reusability provided structurally diverse hybrid molecules with unique combination of privileged substructures. The present synthetic protocol will contribute significantly to drug discovery research in view of its synthetic efficiency to synthesize drug‐like molecules with structural complexity. The catalyst was successfully synthesized and characterized by X‐ray diffraction (XRD), Fourier‐transform infrared spectroscopy (FT‐IR), energy‐dispersive X‐ray spectroscopy (EDX), and transmission electron microscopy (TEM).