Efficient and short synthesis of new camphor sultam based chiral bipyridines and phenanthrolines

Abstract

Starting from bromo substituted bipyridines or phenanthrolines new camphor sultam (10,10-dimethyl-4-aza-3,3-dioxo-thiatricyclo[5.2.1.0 1,5]decane) based chiral chelating ligands are synthesized by copper catalyzed aromatic nucleophilic substitution. Another class of ligands having a methylene linker between the camphor sultam and the heterocycle is established by use of the corresponding bromo methyl derivatives as precursors.