Abstract
Naturally occurring regulatory T cells (nTregs) suppress the development of graft-versus-host disease and may spare graft-versus-tumor effect. As nTreg is a rare cell population in a healthy individual, using in vitro expanded nTregs is a common strategy to test their therapeutic potential in hematopoietic cell transplantation (HCT). However, the concern of in vitro expanded nTregs may include their stability of Foxp3 expression and suppressive function, survival in vivo, and non-selective suppression of pre-activated nTregs.
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