Abstract

An efficient and highly stereoselective method for synthesizing optically active γ-trityloxymethyl-α-alkylidene-γ-butyrolactones having a stereodefined mono or disubstituted exocyclic double bond, starting from commercially available non-racemic glycidyl tritylether has been developed in which a titanium(II)-mediated intramolecular nucleophilic acyl substitution reaction is a key reaction.

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