Efficient and novel one-pot synthesis of antifungal active 1-substituted-8-aryl-3-alkyl/aryl-4 H-pyrazolo[4,5- f][1,2,4]triazolo[4,3- b][1,2,4]triazepines using solid support

Abstract

A simple, efficient and environment-friendly procedure is developed for the synthesis of 1-substitued-8-aryl-3-alkyl/aryl-4 H-pyrazolo[4,5- f][1,2,4]triazolo[4,3- b][1,2,4]triazepines in the presence of N, N-dimethylformamide as an energy transfer medium, p-TsOH as catalyst and basic alumina as solid support under microwave irradiation. The products are obtained in moderate to good yields and are in a state of high purity. Moreover, title compounds have been screened for antifungal activity.