Efficient and Fast Method for the Preparation of Diaryl Ketones at Room Temperature

Abstract

Palladium-catalyzed cross-coupling reaction of aryl­boronic acids with acid chlorides at room temperature under phosphine-free conditions affords the corresponding aromatic ketones in excellent yields within short times. This synthetic method overcomes common disadvantages of Friedel–Crafts acylation procedures and is compatible with both electron-donating and electron-withdrawing substituents on the aryl ring of the acyl chlorides.