Abstract
An efficient and rapid method has been found for the iodination of aromatic compounds using iodine and polymer-supported periodic acid (PSPIA) as an oxidant under mild aprotic conditions. The reagent after the completion of the reaction was easily removed by filtration and was regenerated for further use. This method has some advantages such as: mild reaction conditions, straight forward procedure, inexpensive method, high yields and one-pot conversion. KEY WORDS: Iodine, Polymer-supported periodic acid, Oxidant, Iodination Bull. Chem. Soc. Ethiop. 2014, 28(2), 305-308. DOI: http://dx.doi.org/10.4314/bcse.v28i2.15
Highlights
Iodobenzene derivatives are valuable compounds in organic synthesis, medicine, and biochemistry [1]
The wide range of methods reported until now revealed the lack of an efficient and general enough procedure, but the reaction by iodine or iodide in the presence of oxidants or Lewis acids is common and revealed some efficiency and selectivity [7,8,9,10]
A combination of iodine and polymer-supported periodic acid has been found to be an excellent reagent for the efficient iodination of aromatic compounds
Summary
Iodobenzene derivatives are valuable compounds in organic synthesis, medicine, and biochemistry [1]. To continuation our previous works on the preparation and application of polymersupported reagents in iodination reactions and organic synthesis [11,12,13,14,15,16,17] we report here a practical and efficient aromatic iodination. A combination of iodine and polymer-supported periodic acid has been found to be an excellent reagent for the efficient iodination of aromatic compounds. These reactions are carried out at 40 oC using CH3CN as the solvent.
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