Abstract

Reactions of pyrazine 1-oxides with electrophiles in the presence of LTMP (lithium 2,2,6,6-tetramethylpiperidine) and TMEDA (N,N,N',N'-tetramethylethylenediamine) afforded 2-alkyl- and 2-acylpyrazine 1-oxides in good yields, and the products could be deoxygenated with PBr 3 and Raney Ni successfully

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