Efficiency of treatment of chemoresistant tuberculosis from patients suffering from HIV in Zaporizhzhia region within 2013–2017

Abstract

Purpose of the study. Is to study the efficiency of treatment of tuberculosis from patients suffering from chemoresistant tuberculosis associated with HIV under the conditions of Zaporizhzhia region during 2013–2017.
 Materials and methods. 379 cases of chemoresistant tuberculosis associated with HIV infection were registered in Zaporizhzhia region within 2013–2017. The efficient of treatment of tuberculosis from patients suffering from tuberculosis/HIV co-infection was estimated according to the data of cohort analysis.
 Results and discussion. The results of treatment of tuberculosis from HIV positive patients suffering also from the resistant tuberculosis were very low in 2015; the efficient treatment and the lethality were on the same level – 31,9%. The lethality increased by 1,3 times as compared to 2014. The efficient treatment was only in 41,8% in 2016. There was a high percent of discontinued treatment from patients with resistant forms due to long period of treatment: 25,2% in 2015 and 23% in 2016.
 The improvement of provision of psychological aid to the patients suffering from tuberculosis/HIV co-infection during treatment is a promising trend. Treatment of patients suffering from chemoresistant tuberculosis associated with HIV was estimated as an efficient after additional counseling for 20 patients (57,1%); 5 patients (11,4%) discontinued antitubercular chemotherapy; 6 patients (17,1%) had a treatment failure; there were 5 fatal cases (14,4%).
 Conclusions. The efficiency of treatment of chemoresistant tuberculosis from HIV positive patients in Zaporizhzhia region during 2013–2017 was equal to 41, 45, 31,9, 41,8 and 34,5 percents, respectively, according to the data of cohort analysis. It is necessary to implement the new tests for diagnosis and new treatment regimens for the purpose of the improvement of the efficiency of treatment of chemoresistant tuberculosis from HIV positive patients. However, this will be insufficient without improvement of individual psychological work with patients.