Abstract
Silver nanoflowers (Ag1 and Ag2 NFws) were prepared using combined solid state–polyol reduction methods. The nanoflowers were characterized by X-ray diffraction, scanning electron microscopy, and UV-visible spectroscopy. A new mechanism of Ag NFw formation, based on microstructural investigation, is described. According to this mechanism, Ag1 NFws have a lower free surface energy and are more flexible than Ag2 NFws. Both Ag1 and Ag2 NFws were radiolabeled by adsorption of iodine-125 with the maximum radiochemical yield of 95.6 ± 0.5 and 58.4 ± 0.3%, respectively. The stability and biodistribution of 125I-Ag1 NFws were studied. Ag1 NFws were shown to be localized in the septic inflamed muscle to a greater extent than in a normal muscle. Ag1 NFws show promise as a theranostic agent.
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