Efficiency of intrauterine insemination as a method of treating marital infertility

Abstract

Introduction: Marital sterility is a special problem that the WHO declared as the disease and it is estimated that 15% of couples have been treated by this disease. The causes of marital infertility are 45-50%,of men, 45-50% of women and 5-10% couples of unknown causes. Total fertility rate in Montenegro has been reduced by about 10%. The aim of the study was to make the assessment of successfulness of intrauterine insemination, as one of the methods of treatment of marital infertility. Material and methods: We studied 27 infertile married couples, where 52 cycles were stimulated. In 42 (80.7%) of cycles the ovulation was confirmed and made intrauterine insemination (IUI) by husband's sperm, which was prepared by swim-up modified method. In 10 cycles there has been no adequate growth of follicles and the folliculigenesis stimulation was interrupted. The causes of infertility in the study group were: cause of male infertility (n = 11) mild and easy forms of endometriosis (n = 6) cervical factor (n = 4) and polycystic ovarian syndrome (n = 6). Results: The pregnancy occurred in 4 female patients. Percentage of pregnancy was 10.8%, compared to cycles in which ovulation was confirmed, after which intrauterine insemination was done. Percentage of pregnancy in married couples, according to the different causes of infertility was: infertility caused by cervical factor of 25%, the causes of male infertility 16.6%, with mild or easy endometriosis 18.2%, polycystic ovarian syndrome 16.6%. Discussion: Examination presents prospective study, which included 27 infertile couples, in which ovarian stimulation were performed with Clomifen citrate and made intrauterine insemination. In 18 pairs was about the secondary, and in 9 pairs, the primary infertility. We believe that our results are satisfactorily and consistent with published results in the reference literature. Conclusion: Intrauterine insemination is a cheap and minimally invasive method compared to other methods of assisted reproduction. Numerous reports indicate that the pregnancy rate is much higher if the IUI is combined with controlled ovarian stimulation.