Abstract
Background. Plague is an especially dangerous natural focal infectious disease belonging to a group of quarantine infections. There are eleven natural plague foci in Russian Federation. In Republic Tyva plague endemic territories include Ovyur, Mongun-Taigin and Tes-Hem areas where Y. pestis strains are intermittently isolated from Citellus undulates. Population living at the territory of the natural foci get immunoprophylaxis against plague at complication of epizootic and epidemic conditions.This paper presents the results of monitoring indicators of the immune status of people vaccinated with the plague vaccine living in the territory of the Tuva natural focus.Materials and methods. The study involved 76 volunteers who had not previously been vaccinated. The study included the determination of production IFN-γ, IL-4, TNF-α by blood cells, titers of specific IgG antibodies to the capsule F1 antigen of the Yersinia pestis, and concentrations of immunoglobulins in serum blood, as well as immunophenotyping of blood lymphocytes.Results. In the course of a comprehensive immunological study, features of the development of cellular and humoral reactions in people living in the territory of the Tuva natural plague focus were established in the first months after vaccination. Changes in the concentration dynamics of the main classes of immunoglobulins were accompanied by an increase in the level of specific IgGs to the F1 within 6 months after immunization. In the same period, a significant increase in the production of cytokines, as well as significant changes in terms of the subpopulation composition of the vaccinated blood.Conclusion. It is necessary to note the importance of studying of the human immune status in 1–3 months after plague vaccination as this period coincides with potentially dangerous season from epidemiological point of view. Nevertheless, much important role for improvement of tactics of the specific prevention measures plays the data received after the revaccination.
Highlights
Plague is an especially dangerous natural focal infectious disease belonging to a group of quarantine infections
This paper presents the results of monitoring indicators of the immune status of people vaccinated with the plague vaccine living in the territory of the Tuva natural focus
The study included the determination of production IFN-γ, IL-4, TNF-α by blood cells, titers of specific IgG antibodies to the capsule F1 antigen of the Yersinia pestis, and concentrations of immunoglobulins in serum blood, as well as immunophenotyping of blood lymphocytes
Summary
Оценка эффективности вакцинации населения против чумы в Тувинском природном очаге Корытов К.М. 1, Войткова В.В. 1, Дубровина В.И. 1, Пятидесятникова А.Б. 1, Носков А.К. 1, Глушков Э.А. 2, Акимова И.С. 2, Ондар Н.В. 2, Салчак Л.К. 3, Монгуш О.С. 3, Дажикай А.Д. 3, Сайды А.А. 4, Ортеней Ю.К. 5, Балахонов С.В. 1. Оценка эффективности вакцинации населения против чумы в Тувинском природном очаге Корытов К.М. На территории Российской Федерации расположены 11 природных очагов чумы. В работе представлены результаты мониторинга показателей иммунного статуса вакцинированных чумной вакциной людей, проживающих на территории Тувинского природного очага. В исследовании приняли участие 76 добровольцев, ранее не вакцинированных и проживающих на энзоотичной территории по чуме, расположенной в непосредственной близости от Боро-Шайского мезоочага Тувинского природного очага чумы. Отмечена важность изучения иммунного статуса людей в 1–3-й месяц после вакцинации против чумы, поскольку этот период приходится на потенциально опасный в эпидемиологическом отношении сезон. Для цитирования: Корытов К.М., Войткова В.В., Дубровина В.И., Пятидесятникова А.Б., Носков А.К., Глушков Э.А., Акимова И.С., Ондар Н.В., Салчак Л.К., Монгуш О.С., Дажикай А.Д., Сайды А.А., Ортеней Ю.К., Балахонов С.В. Оценка эффективности вакцинации населения против чумы в Тувинском природном очаге.
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