Abstract
The purpose of the research to study the antihelminthic efficiency of the new antihelminthic medication asmegum. Materials and methods. The object of the research is the antihelminthic medication asmegum, which has been synthesized at the Institute of Chemistry and Chemical Technologies of the National Academy of Sciences of the Kyrgyz Republic by streamlined synthesis. Asmegum was tested on 45 spontaneously infested sheep born in 2015 with the body weight of about 40-50 kg at the experimental base of the Kyrgyz Scientific Research Institute of Veterinary named after A. Duysheev. Animals were divided into 9 groups, 5 animals in each group, according to the principle of analogues. All test animals were kept under the same conditions. Asmegum was given orally as a single dose in the form of water emulsion, powder and medicated feed mixture at a dose of 50 mg/kg of live weight. Animals from the 1st, 2nd and 3rd groups received asmegum in a water emulsion form. Animals from the 4th, 5th and 6th groups received the medication in a powder form. Sheep from the 7th, 8th and 9th groups received asmegum in a medicated feed mixture form. The animals were monitored during 10 days. The anthelminthic activity of the medication was determined according to the results of coproovolarscopical (by Fulleborn's method, sequential washing method and Berman's method) research in 10 days after giving medication. The therapeutic efficiency of the anthelmintic agent was assessed according to the requirements of the World Association for the Advancement of Veterinary Parasitology (1995). Results and discussion. The asmegum efficiency at a dose of 50 mg/kg versus strongylata, nematodiroses and dicrocelium was determined. Its efficiency in strongylatosis, dicroceliosis and nematodirus was 90.3-91.28%, 89.76-92.0% and 86.52-91.56% respectively. The medication dosage form did not effect its efficiency. Asmegum administration in a recommended dose did not induce adverse events in animals. The medication promoted the intestine function regeneration. Sheep treated with asmegun bulked up quickly due to presence of asparaginic acid in its composition.
Highlights
Medicated feed mixture at a dose of 50 mg/kg of live weight
The anthelminthic activity of the medication was determined according to the results of coproovolarscopical research in 10 days after giving medication
The therapeutic efficiency of the anthelmintic agent was assessed according to the requirements of the World Association for the Advancement of Veterinary Parasitology (1995)
Summary
Мыктыбек Адрасулович Исаев 1, Момун Арзыбаевич Арзыбаев 2, Азизбек Бакаевич Шакиров 3. Цель исследований: изучение антигельминтной эффективности нового антигельминтного препарата асмегума. Асмегум применяли перорально однократно в форме водной эмульсии, порошка и кормолекарственной смеси в дозе 50 мг/кг живой массы. Животным 1, 2 и 3-й групп асмегум задавали в форме водной эмульсии. Животные 4, 5 и 6-й групп получили препарат в форме порошка. Овцам 7, 8 и 9-й групп задавали асмегум в форме кормолекарственной смеси. Установлена эффективность асмегума в дозе 50 мг/кг против стронгилят, нематодир и дикроцелий. Дикроцелиозе и нематодирозе составила соответственно 90,3–91,28%, 89,76–92,0 и 86,52–91,56%. Лекарственная форма препарата не влияла на его эффективность. Введение асмегума в рекомендуемой дозе не вызывало у животных побочных явлений. Ключевые слова: антигельминтик, асмегум, лекарственная форма, стронгилята, нематодиры, дикроцелии, эффективность. Б. Эффективность асмегума при смешанных гельминтозах овец // Российский паразитологический журнал.
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