Abstract
The current ecological situation in large industrial cities is characterized by a negative impact on all elements of ecosystems, among which heavy metals are priority. The purpose of this study was to assess the effect of manganese load on the body of laboratory animals. The study was performed on female rats of mature age (3 months) weighing 200±10 g (n=18). The study evaluated the oral administration of manganese sulfate for 28 days using the behavioral and cognitive functions of laboratory animals using tests “Open field”, “Light-dark transition test” and the installation “Water maze test”. In animals, there was a decrease in interest in examining holes, an increase in acts of defecation and grooming, and a manifestation of passive fear in the new environment. The results of the “Water maze test” showed violations of spatial memory and the learning process in animals receiving manganese sulfate. It can be concluded that the salt of manganese sulfate has a negative effect on the central nervous system of animals.
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