Efficiency and biocompatibility of antimicrobial textile material of broad spectrum activity

Abstract

AbstractThe subject of this article is to study the behavior of the antimicrobial textile material. The material is in the form of plaster wound dressing which is consisting of a nonwoven textile base containing polypropylene (PP)/viscose, a polymer carrier, and an antimicrobial active substance. The polymer carrier is the polysaccharideD‐glucosamine (chitosan), and the active antimicrobial substance is antibiotic gentamicin sulfate. The amount of gentamicin sulfate immobilized into the polymer matrix of the polymer carrier was 0.15–0.20 mg/cm2or 2.0–2.5% of the mass of the nonwoven textile material. The antimicrobial textile material has been studiedin vitroandin vivoconditions through the efficiency of the antimicrobial effects on different kinds of pathogenic microorganisms, as well as the biocompatibility in preclinical research. The results of these experiments indicate that all bioactive textile materials were biocidalin vitrofor all pathogenic test organisms. Good biocompatibility, the existence of the correlation between thein vitroandin vivoresults, concerning efficiency, qualifies these antimicrobial biomaterials for clinical use. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011