Abstract
BackgroundVisceral fat area (VFA) is a good surrogate marker of obesity-related disorders, such as hypertension, dyslipidemia and glucose intolerance. Although estimating the VFA by X-ray computed tomography (CT) is the primary index for visceral obesity, it is expensive and requires invasive radiation exposure. Dual bioelectrical impedance analysis (BIA) is a simple and reliable method to estimate VFA; however, the clinical usefulness of dual BIA remains unclear in patients with type 2 diabetes (T2D).MethodsWe estimated the VFAs by dual BIA and CT in 98 patients with T2D and assessed anthropometric parameters, blood test results, and the presence of comorbid hypertension and dyslipidemia. We compared the correlation between the VFAs examined by dual BIA and CT. Furthermore, we performed the receiver operating characteristic (ROC) analyses for the VFAs to detect the presence of comorbid hypertension and/or dyslipidemia with T2D, which are major comorbidities of visceral obesity, and estimated the area under the curve (AUC).ResultsThe measurement error between the VFAs by dual BIA and CT was significantly higher among patients with brain natriuretic peptide (BNP) ≥ 100 pg/mL than those with BNP < 100 pg/mL (39.2% ± 31.1% vs. 24.1% ± 18.6%, P < 0.05). After excluding patients with BNP ≥ 100 pg/mL, the VFA by dual BIA significantly correlated with the VFA by CT (r = 0.917; P < 0.0001). The AUC in the ROC analysis for the VFA by dual BIA to detect the presence of comorbid hypertension and/or dyslipidemia with T2D was almost equivalent to that for the VFA by CT.ConclusionsIn patients with T2D without elevated BNP > 100 pg/mL as indicator for fluid accumulation interfering with BIA, estimation of the VFA by dual BIA significantly correlated with that by CT and also detected comorbid hypertension and/or dyslipidemia with T2D equivalent to those detected by CT. Hence, dual BIA could be an alternative to CT as a standard method for estimating the VFA in patients with diabetes.
Highlights
Visceral fat area (VFA) is a good surrogate marker of obesity-related disorders, such as hypertension, dyslipidemia and glucose intolerance
Precisely measuring entire visceral fat amount is difficult, Omura‐Ohata et al Cardiovasc Diabetol (2019) 18:137 the visceral fat area (VFA) estimated by X-ray computed tomography (CT) at umbilical level has been reported as a good surrogate marker of obesity-related disorders, especially such as hypertension, dyslipidemia and glucose intolerance [9,10,11,12]
A significant correlation between the VFA measured by dual bioelectrical impedance analysis (BIA) (VFA-BIA) and the VFA measured by CT (VFA-CT) has been reported in healthy subjects [14]
Summary
Visceral fat area (VFA) is a good surrogate marker of obesity-related disorders, such as hypertension, dyslipidemia and glucose intolerance. Omura‐Ohata et al Cardiovasc Diabetol (2019) 18:137 the visceral fat area (VFA) estimated by X-ray computed tomography (CT) at umbilical level has been reported as a good surrogate marker of obesity-related disorders, especially such as hypertension, dyslipidemia and glucose intolerance [9,10,11,12]. This method is expensive and requires radiation exposure, and it is not useful for ubiquitous and frequent use. This study aimed to assess the correlation between the VFA-BIA and VFA-CT in patients with T2D and examined the clinical usefulness of the VFA-BIA to evaluate visceral obesity by comparing to the VFA-CT the ability of detecting the presence of comorbid hypertension and/or dyslipidemia with T2D patients
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