Abstract
Aim: To assess the efficacy of various irrigants used with Self-Adjusting File (SAF) system on smear layer.
 Materials and Methods: Forty extracted mandibular teeth were taken and decoronated. All samples were instrumented manually up to number 20 K file. SAF file was further used to prepare the canals. All the samples were randomly divided into four Groups: Group I: Neem Extract Group II: Amla Juice; Group III: 5.25% NaOCl+ 20% Citric Acid; Group IV: 5.25% NaOCl solution was used for 4minutes. All roots were sectioned longitudinally in the buccolingual plane and viewed under electron microsope.
 Statistical Analysis Used: The Kruskal-Wallis test was used for statistical evaluation and Mann-Whitney ???? test was used for multiple comparisons
 Results: Comparison between same thirds of group showed statistically significant difference in coronal and middle parts. Group 3 showed the best results for smear layer removal. Group 4 showed least efficacy of smear layer removal.
 Conclusion: Group 3 showed the best removal efficacy followed by group 1 and 2 with least being for group 4.
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