Abstract
The article presents the results of studying the efficacy of the drug based on granulocyte-macrophage colony-stimulating factor (GM-CSF) in cows with postpartum ovarian hypofunction. It has been established that its twofold administration at a dose of 10.0 ml/animal with a 7-day interval ensures the restoration of sexual cyclicity in 90.0% of cows with a reduction in the length of infertility by 18.0-30.1 days and the fertilization coefficient – by 0.56-0.78. A twofold use of the drug based on GM-CSF at a dose of 10.0 ml is accompanied by the development of dominant follicles, the diameter of which is by 46.6% larger compared to saline, an increase in the level of DHEA-S by 2.0 times, estradiol-17β – by 29.3%, which ensures a full manifestation of sexual cyclicity.
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