Abstract
PurposeThe aim of the study was to evaluate the efficacy of transcatheter arterial chemoembolization (TACE) in treating patients with liver metastases from pancreatic cancer, and explore the prognostic risk factors.ResultsThree of the 27 patients were totally recovered, and 12 were partially alleviated. The total efficacy rate was 55.6% (15/27). The median survival time was 13.6 months, and the 0.5-, 1-, 2-, 3-, and 5-year survival rates were 70.4% (19/27), 48.1% (13/27), 22.2% (6/27), 14.8 (4/27), 11.1% (3/27), respectively. None of the groups showed any severe complications. Univariate analysis showed that pathological type, concomitant therapies for liver metastasis, vascular supply, CA199 levels and extrahepatic metastasis were related to prognosis (P < 0.05). Multivariate analysis indicated that pancreatic cancer pathology and extrahepatic metastasis were independent risk factors influencing patients' prognosis (χ2 = 13.182, 17.989, P < 0.05).MethodsThe clinical records of 27 patients with lliver metastases from pancreatic cancer diagnosed at the First Affiliated Hospital of Zhejiang University between May 2009 and May 2015 were retrospectively analyzed. The short-term and long-term efficacy and toxic side effects of TACE were observed. The prognostic risk factors were analyzed using Cox (proportional hazards) regression model.ConclusionTACE is an effective therapy for treating liver metastases from pancreatic malignancy. Pathological type and extrahepatic metastasis of pancreatic tumor are independent risk factors for patients' prognosis. The prognosis of patients with liver metastasis from pancreatic neuroendocrine neoplasm is superior to that of extrahepatic metastasis.
Highlights
Pancreatic malignancy ranks tenth or eleventh among all malignancies in China [1]
Recent technological advances suggest that micro-traumatic interventions, such as transcatheter arterial chemoembolization (TACE), are clinically effective for the treatment of liver metastases arising from pancreatic malignancy[5,6]
The first TACE therapy included cases of single liver metastasis and cases of liver metastases combined with extrahepatic lesions
Summary
Pancreatic malignancy ranks tenth or eleventh among all malignancies in China [1]. The overall survival (OS) for patients with liver metastases from pancreatic cancer is only 11.1 months [4]. Chemoradiotherapy is recommended for pancreatic cancer metastases. Performance status, tumor and serum markers, disease burden, and www.impactjournals.com/oncotarget metastatic pattern have been described as prognostic and predictive factors for survival in pancreatic cancer patients[5]. Recent technological advances suggest that micro-traumatic interventions, such as transcatheter arterial chemoembolization (TACE), are clinically effective for the treatment of liver metastases arising from pancreatic malignancy[5,6]. We retrospectively analyzed the early-stage efficacy of TACE in 27 patients with pancreatic liver metastases, and explored the related prognostic factors
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