Abstract
Melasma is one of the common pigmentary problems affecting females in our community, owing to the frequent use of hormonal contraceptives as well as our sunny climate. A lot of treatment options are available but none of them is completely satisfactory. Many patients prefer the use of topical preparations and minimally invasive methods. Tranexamic acid (TA) is a potential treatment option for hyperpigmentation with different delivery routes. We designed the study in order to evaluate the efficacy of TA in melasma using 2 different routes of delivery. A randomised clinical trial was performed on 60 female patients with melasma, they randomly divided into three groups; A, B and C. Group (A) patients received TA (4mg/mL) intradermal injections every 2weeks with, group B received TA (10mg/mL) intradermal injections every 2weeks, group C received TA cream (10% concentration) twice daily, treatment continued for 12weeks in all groups. Melasma Area and Severity Index (MASI) scores were measured for each patient before and after completion of treatment. The percentage of MASI score reduction was highest in group B (62.7%) versus (39.1%) in group A, while the percentage of MASI reduction was the lowest in group C (4.2%). Tranexamic acid is a safe effective and well-tolerated treatment option for melasma patients. Intradermal injection of TA leads to better results than the topical application. Topical TA cream (even in a high concentration) produce fair improvement of melasma.
Published Version
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