Efficacy of Tooth Extraction Wound Protection Made of Atelocollagen Sponge (TRE-641): A Pilot Study in Dogs

Abstract

To evaluate the efficacy of tooth extraction wound protection made of atelocollagen sponge (TRE-641), we observed healing in tooth extraction sites filled with TRE-641 and those filled with a control material, oxide cellulose. Subjects were 11 beagle dogs, with a total of 22 extraction sites. Both maxillary lateral incisors were carefully removed, and extraction wounds were filled with TRE-641 on one side and with oxidized cellulose sponge as control on the other side. Wound healing was observed, and the animals were sacrificed at 7, 14, and 28 days after surgery. We compared extent of bone formation, hematoma, inflammation, and graft material remaining between the two groups. At 7 days, newly formed bone extending from the floor and wall of the socket bone were seen in the TRE-641. Hematoma and inflammation were observed in the oxide cellulose. At 14 days, a small amount of TRE-641 remained. In the oxide cellulose group, a small amount of hematoma remained. At 28 days, the extraction socket was filled with newly formed bone in both groups. TRE-641 produced acceptable early phase bone healing at the tooth extraction site with no remnant graft material with sufficient bone formation of the tooth extraction wound.