Abstract
In patients with polyarticular course of juvenile idiopathic arthritis (JIA) both, ongoing chronic inflammation with high levels of pro-inflammatory cytokines and corticosteroid treatment, may affect linear growth adversely, potentially leading to irreversible growth retardation. Biologic treatment of JIA may have the potential to enable normal growth in children with JIA.
Highlights
In patients with polyarticular course of juvenile idiopathic arthritis (JIA) both, ongoing chronic inflammation with high levels of pro-inflammatory cytokines and corticosteroid treatment, may affect linear growth adversely, potentially leading to irreversible growth retardation
Clinical response in TNFa blocker + MTX group was accompanied by catch-up in 18 patients, “steady growth” and impaired growth were observed in 8 cases both
Clinical response in control group was accompanied by catch-up only in 3 cases, “steady growth” and impaired growth were observed in 6 and 8 patients respectively
Summary
In patients with polyarticular course of juvenile idiopathic arthritis (JIA) both, ongoing chronic inflammation with high levels of pro-inflammatory cytokines and corticosteroid treatment, may affect linear growth adversely, potentially leading to irreversible growth retardation. Biologic treatment of JIA may have the potential to enable normal growth in children with JIA
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