Abstract
Objective: To assess the effectiveness of Tilmicosin in the treatment of pasteurellosis in Holstein calves. Design: Controlled study. Animals: TwentyHolstein Calves Procedures: 10 Holstein Calves suspected to be suffering from Bovine respiratory distress (BRD) were treated with Tilmicosin and another 10 Holstein healthy calves under the same conditions of hygiene, nutrition, and management were used as a control group. The nasal swap was collected from the two groups for bacteriological isolation and blood samples were collected for hematological and biochemical analysis at zero, 7th, 14th days. Results: Bacteriological isolation revealed that Pasteurella multocida and Mannheimia haemolytica serotype A were the most causative agents of pasteurellosis in the infected calves. The hematological analysis of the tilmicosin treated group showed a significant decrease (P 0.05) in hemoglobin, but there is a significant decrease in hematocrit at Zero Week and second week, and a significant decrease (P<0.05) of MCV at zero week and first week, with a significant increase of MCH at zero weeks, with a significant increase in MCHC at zero weeks and the second week with a significant increase in Plt at second week, a significant decrease in lymphocyte at zero week and second week but there is a significant increase of neutrophil at zero weeks and the second week with a significant decrease at the first week. The biochemical analysis showed no significant change in total protein and albumin with a significant increase in GOT at the first week, a significant decrease in GPT at second week, a significant increase in ALP at Zero weeks, and first week there is a significant increase in Gb at zero weeks, first week and second week, albumin concentration was significantly decreased, a significant decrease of creatinine at zero weeks and a significant increase in the first week. Conclusion and clinical relevance: In conclusion, tilmicosin induced a significant decrease in RBCs & lymphocyte and a significant increase in WBCs, neutrophil, platelets, and globulin.
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