Efficacy of thoracic catheter combined with anti-tuberculosis drugs in the treatment of pleural effusion in patients with tuberculous

Abstract

Objective To analyze the efficacy of the treatment of tuberculous pleurisy combined with pleural effusion in patients with pleural effusion. Methods Patients (n=130) with tuberculous pleural effusion in Department of Surgery, Jingmen Second People′s Hospital of Hubei Province, from March 2014 to December 2015 were retrospective study, and these patients were divided into observation group (n=65) and control group (n=65) by random number table. The control group was given traditional methods thoracentesis and observation group was taken the chest tube injection medicine combined therapy with anti-tuberculosis drugs, respectively. The treatment effect, adverse reaction and the recurrence rate, etc. were analyzed between groups. Measurement data were represented as ±s, and comparsion between groups was analyzed using the t test. Count data were evaluated by the percentage, and comparsion between groups was analyzed using the chi-square test. Results The effective rate (40%) and total effective rate (93.85%) of the patients in the observation group were significantly higher than those in the control group (P<0.05); In the observation group, the flow rate of pleural effusion (3 500±500) ml more than in the control group (P<0.05); the disappearing time (6.92±1.13) d were significantly shorter than in the control group (P<0.05); the value of pleural thickness change (1.67±0.35) mm of the patients in the observation group was significantly greater than that of the control group (P<0.05); the protein content of pleural effusion (14.78±2.16) g/L was significantly higher than that in the control group (P<0.05); the incidence of pleural thickening (1.54%), vomiting rate (1.54%), chest pain rate (4.62%) and fever incidence (1.54%) in the observation group were significantly lower than those in the control group (P<0.05); the total incidence of adverse reactions in the observation group (9.23%) was significantly lower than that of the control group (P< 0.05). After 6 months of follow-up, the recurrence rate of the patients in the observation group (0) was significantly lower than that of the control group (4.61%)(P<0.05). Conclusion Pleurisy pleural effusion in patients with tuberculous pleural catheter injection of anti-tuberculosis drugs can improve the therapeutic effect, reduce adverse reactions with application value. Key words: Tuberculosis, pleural; Antitubercular agents; Pleural effusion; Pleural catheterization