Abstract
Objective: The objective of the study was to show the efficacy of teriparatide in comminuted fracture healing and improvement in overall functional recovery. Methods: A total of 30 subjects who suffered from comminuted fractures of lower limb were selected. Subjects were categorized into two groups: Group A (n=15) contained individuals with teriparatide administration and Group B (n=15) contained individuals who were not administered teriparatide. 20 mg of teriparatide was injected subcutaneously for a period of 3 months. Patients were followed up ay durations of 4, 8, and 12 weeks. Obtained data were entered into Microsoft Excel Worksheets and descriptive analysis was performed. Chi-square test was used to analyze all obtained data. Results: Among Group A patients, the fracture healing rates were found to be significantly earlier with comparison to control group (Group B). Conclusion: Teriparatide was observed to be effective in comminuted fracture healing and has demonstrated good clinical outcome.
Highlights
Delayed fracture union or healing may be defined as a state wherein union of bone does not take place even following lapse of adequate time period from the tome of injury while non-union of fractured segments is the result of delay in union of fractures which as per the American Food and Drug Administration or FDA is a minimum period of 9 months
Fracture union was seen to occur in nine patients with no visible fracture line in Group A
Subjects treated with teriparatide demonstrated earlier mobilization compared to those without (p=0.02) (Table 1 and Graph 1)
Summary
Delayed fracture union or healing may be defined as a state wherein union of bone does not take place even following lapse of adequate time period from the tome of injury while non-union of fractured segments is the result of delay in union of fractures which as per the American Food and Drug Administration or FDA is a minimum period of 9 months. A comminuted fracture may be defined as a fracture with multiple bone fragments. It is caused by a crushing or compression force along the long axis of a bone. It is not possible to satisfy these criteria most of the times, a clinician makes use of clinical and radio-graphical parameters to define a non-union or delay in union of bone fractures [1]. Factors specific to fracture: (a) Minor trauma or injury; (b) sever loss of bone; (c) inadequate amount of fracture reduction and immobilization; (d) application of distraction; (e) inadequate vascular supply; (f) formation of massive hematoma; and (g) extended use of nonsteroidal anti-inflammatory drugs [1]
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