Abstract
BACKGROUND & OBJECTIVE: Benign prostatic hyperplasia (BPH) is a prevalent cause of voiding problems in older males and is most commonly associated with acute urological complications, most important of which is acute urinary retention (AUR). α1- antagonists are the treatment of choice for the management of patients with BPH. Our objective was to evaluate the efficacy of tamsulosin for the treatment of patients with AUR due to BPH in terms of trial without catheter (TWOC).
 METHODOLOGY: This randomized control trial was conducted in a Urology Section, Department of Surgery, SIUT Karachi, from 21-12-2016 to 20-06-2017. Our study included 136 patients who presented AUR due to BPH as per selection criteria. Patients were randomized into two groups. Group A patients received tamsulosin (0.4 mg), and group B patients received placebo drug immediately after insertion of Foley catheter. The success of TWOC was evaluated after 3 days of medical treatment. Statistical analysis was carried out using SPSS v20.0.
 RESULTS: The mean age of the study patients was 59.45 + 8.05 years. The mean duration of BPH disease was 15.39 + 6.84 months. There were 33 (48.5%) patients in the tamsulosin group in which TWOC was successful and only 22 (32.4%) patients in placebo group in which TWOC was successful (p-value 0.04). There was no effect of age and duration of BPH disease on the outcome of this study.
 CONCLUSION: Tamsulosin is effective for the treatment of patients with AUR due to BPH.
Highlights
Benign prostatic Hyperplasia (BPH) is a common cause of voiding dysfunction in men
Tamsulosin is effective for the treatment of patients with acute urinary retention (AUR) due to BPH
The objective of the study is to evaluate the efficacy of Tamsulosin for the treatment of patients with AUR due to BPH in terms of trial without catheter (TWOC)
Summary
Benign prostatic Hyperplasia (BPH) is a common cause of voiding dysfunction in men The prevalence of this disease increases with advancing age. We conducted this study in patients with acute urinary retention in a tertiary care center to find out the efficacy of tamsulosin in the management of AUR. The objective of the study is to evaluate the efficacy of Tamsulosin for the treatment of patients with AUR due to BPH in terms of TWOC. Benign prostatic hyperplasia (BPH) is a prevalent cause of voiding problems in older males and is most commonly associated with acute urological complications, most important of which is acute urinary retention (AUR). Our objective was to evaluate the efficacy of tamsulosin for the treatment of patients with AUR due to BPH in terms of trial without catheter (TWOC)
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