Abstract

D Di Bona, A Plaia, MS Leto-Barone, S La Piana, G Di Lorenzo. J Allergy Clin Immunol. 2012;130(5):1097–1107, e2 To compare the efficacy of subcutaneous (SCIT) and sublingual immunotherapy (SLIT) to grass by meta-analysis of double-blind, placebo-controlled trials. Among 36 studies selected for this meta-analysis, 14 included children. An electronic literature search identified 36 randomized controlled trials (RCTs) comparing SCIT and SLIT to placebo for grass pollinosis. All the studies assessed symptom scores and 31 assessed medication scores as outcome measures. To standardized comparative studies, the authors used the “standard mean difference” method (SMD) to compare SCIT or SLIT versus placebo. A “fail-safe” number (the number of insignificant or missing studies that would need to be added to a …

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