Abstract
BackgroundBurns remain a serious public health problem with high morbidity and mortality rates worldwide. Although there are various treatment options available, there is no consensus on the best treatment for severe burns as of yet. Stem cell therapy has a bright prospect in many preclinical studies of burn wounds. The systematic review was performed for these preclinical studies to assess the efficacy and possible mechanisms of stem cells in treating burn wounds.MethodsTwenty-two studies with 595 animals were identified by searching PubMed, EMBASE, Web of Science, and Cochrane Library databases from inception to 13 May 2020. In addition, a manual search of references of studies was performed to obtain potential studies. No language or time restrictions were enforced. RevMan 5.3 was used for all data analysis.ResultsThe overall meta-analysis showed that stem cell therapy significantly improved burn healing rate (SMD 3.06, 95% CI 1.98 to 4.14), irrespective of transplant type, burn area, and treatment method in the control group. Subgroup analyses indicated that hair follicle stem cells seemed to exert more beneficial effects on animals with burn wounds (SMD 7.53, 95% CI 3.11 to 11.95) compared with other stem cells. Furthermore, stem cell therapy seemed to exert more beneficial effects on burn wounds with second-degree (SMD 7.53, 95% CI 3.11 to 11.95) compared with third-degree (SMD 2.65, 95% CI 1.31 to 4.00).ConclusionsMeta-analysis showed that stem cell therapy exerts a healing function for burn wounds, mainly through angiogenesis and anti-inflammatory actions. These findings also demonstrate the need for considering variations in future clinical studies using stem cells to treat a burn wound in order to maximize the effectiveness. In general, stem cells can potentially become a novel therapy candidate for burn wounds.
Highlights
Even at current medical levels, burn remains a serious public health problem with high morbidity and mortality worldwide [1, 2]
After careful full-text of the remaining 95 articles, 73 were excluded for the following reasons: (1) failed to obtain available information, (2) stem cell therapy combined with other therapy in experimental group, (3) no proper control group, (4) duplicated report of the same study, and (5) not randomized controlled trials
The present study indicated that stem cell therapy exerted the potential function of burn wound healing through anti-inflammatory action and promotion of angiogenesis
Summary
Even at current medical levels, burn remains a serious public health problem with high morbidity and mortality worldwide [1, 2]. There are various treatment options, there is no consensus yet on the best treatment for severe burns such as deep partialthickness and full-thickness burns. Burns remain a serious public health problem with high morbidity and mortality rates worldwide. There are various treatment options available, there is no consensus on the best treatment for severe burns as of yet. Stem cell therapy has a bright prospect in many preclinical studies of burn wounds. The systematic review was performed for these preclinical studies to assess the efficacy and possible mechanisms of stem cells in treating burn wounds
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