Abstract
Background and Objective: Acinetobacter baumannii is considered as a main opportunistic pathogen in hospitals and exhibit high resistance against most antibiotic groups. The aim of this study was to evaluate the efficacy of some antibiotics and essential oils against this bacterium, in vitro. Materials and Methods: Two hundred and one clinical samples were collected from the Children’s Hospital of Damascus. The polymerase chain reaction was conducted to identify the genus and type of bacteria. Finally, the minimum inhibitory concentrations of several antibiotics and essential oils, including Thymus syriacus, Origanum syriacum, Citrus aurantium, Cinnamomum verum, Syzygium aromaticum, Cupressus macrocarpa, Myristica fragrans, Biota orientalis, and Zingiber officinale, were investigated on Luria-Bertani broth agar. Results: Fifty-nine isolates of A. baumannii were identified and the results showed that the DNA fragments of 16S rRNA and the blaOXA-51 _ like gene were approximately equal to 280 bp and 350 bp, respectively. In addition, most effective antibiotics against 50% of bacteria in each isolate of A. baumannii were rifampicin, linezolid, and levofloxacin whereas most effective essential oils included Cupressus macrocarpa, Citrus aurantium, Myristica fragrans, and Biota orientalis.
Highlights
Background and ObjectiveAcinetobacter baumannii is considered as a main opportunistic pathogen in hospitals and exhibit high resistance against most antibiotic groups
Considering the above-mentioned explanations, this study aimed to conduct a survey on the antibacterial activity of several antibiotics and essential oils, in vitro, against the isolates of A. baumannii obtained from children
Identification of Bacteria The results showed that 67 isolates were positive when cultured on selective media (42%)
Summary
Acinetobacter baumannii is considered as a main opportunistic pathogen in hospitals and exhibit high resistance against most antibiotic groups. Most effective antibiotics against 50% of bacteria in each isolate of A. baumannii were rifampicin, linezolid, and levofloxacin whereas most effective essential oils included Cupressus macrocarpa, Citrus aurantium, Myristica fragrans, and Biota orientalis. Acinetobacter baumannii (A. baumannii) is a bacterium that is classified as opportunistic pathogens in hospitals, especially in immunocompromised patients and children Regarding their role as pathogens, some studies in the last two decades have shown their involvement in many human infections, especially in intensive care units [1,2]. They are isolated from different locations within the hospitals (e.g., air, water faucets, bedsides, gloves, and catheters) This type of infection is associated with war-wounded due to the direct contamination of wounds in the surrounding environment. Other studies demonstrated that most clinical isolates of A. baumannii were resistant to most cephalosporins [6], and this bacterium was completely resistant to aztreonam, cefotaxime in addition to amoxicillin-clavulanic acid combination [7]
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