Efficacy of Skinfill plus filler in the management of facial aging: a multicenter, post-marketing clinical study

Antonella Savoia,Alfonso Baldi,Nicoletta Onori

doi:10.1186/s41702-017-0019-y

Abstract

BackgroundInjectable dermal fillers are commonly used by physicians in the treatment of the signs of aging. The most commonly used dermal filler is hyaluronic acid. Skinfill plus (SFP) belongs to the family of monophasic monodensified fillers. In this post-marketing clinical study, we have evaluated the efficacy of SFP for the treatment of facial aging.MethodsThe study enrolled 109 patients in three different centers that were treated with various SFP fillers to treat facial aging. Analyses of the cosmetic effects were performed by using the Wrinkle Severity Rating Scale (WSRS) and the Global Aesthetic Improvement Scale (GAIS).ResultsStatistical analysis showed a significant effect on facial aging for all the SFP fillers used at all time-points studied. Moreover, a significant correlation was found, by analyzing the grade of facial aging, calculated by using the WSRS or the lifestyle of the patients (smokers or non-smokers) in relation to the cosmetic effects of the treatment.ConclusionsThe study confirms the good performance and safety of SFP for a range of facial indications in routine clinical practice.

Highlights

Injectable dermal fillers are commonly used by physicians in the treatment of the signs of aging
In detail, (a) Silver is indicated for the correction of periocular wrinkles and it has to be injected in the superficial derma, (b) Gold is injected in the middle derma, and (c) Diamond is equipped with greater density and, indicated for the re-harmonization of facial contours, for the increase of soft tissues, and for the treatment of the folds of the nose genus furrow
In a small number of patients (10% of patients), hematomas have occurred and areas of hyperemia associated with itchiness or pain in case of pressure after the injection disappeared in a few days, following the application of anti-edemigen creams

Summary

Introduction

Injectable dermal fillers are commonly used by physicians in the treatment of the signs of aging. Skinfill plus (SFP) belongs to the family of monophasic monodensified fillers In this post-marketing clinical study, we have evaluated the efficacy of SFP for the treatment of facial aging. Injectable dermal fillers have challenged the use of more invasive esthetic surgical procedures, emerging into the armamentarium of products used by physicians in the treatment of the signs of aging (Brandt & Cazzaniga, 2008; Carruthers et al, 2009; Palm, 2014). HA is a glucosaminoglycan biopolymer composed of strands of repeating chains of D-glucuronic acid and N-acetyl-Dglucosamine (Lee et al, 2015). HA is commonly found in the muscle, synovial fluid, skin, and vitreous body of the eye, in the

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