Efficacy of single application of topical doxycycline hyclate and triamcinolone acetonide in denture adhesive in the management of recurrent aphthous stomatitis: A comparative study

Abstract

Aim: This study aims to evaluate the efficacy of single application of topical doxycycline hyclate and triamcinolone acetonide only once as a new therapeutic regimen in the management of recurrent aphthous stomatitis for pain reduction. Materials and Methods: A total of 30 patients were included among which 15 patients were taken into each group. Patients with aphthous ulcer were diagnosed on clinical examination, pain intensity was noted using a visual analog scale (VAS) of 0–10 (with 1 mm division, where “0” is no pain and “10” is worst possible pain), number of ulcers, size of each ulcer, and the duration of each ulcer were recorded. Group I was treated with doxycycline hyclate fine powder mixed in denture adhesive and applied onto the lesion. Group II was treated with 0.1% triamcinolone acetonide gel mixed in denture adhesive and applied onto the lesion. A pain scale sheet was given to each patient to self-evaluate the daily status of pain scale on the day after treatment and daily after that for 7 days. Results: Pain intensity on VAS scale in Group I was 4.27 before treatment and 2.27 after treatment. Similarly, in Group II was 3.60 before treatment and 2.13 after treatment. Pain reduction in VAS-after treatment in 15 Group I patients was 46.8% after treatment on day 1. Moreover, in Group II was 40.8% after treatment on day 1. Group I had faster ulcer healing 2.87 ± 0.743 days when compared to Group II 5.13 ± 0.915 days with the P value of ( Conclusion: Healing of the ulcer was significantly faster with doxycycline treatment compared to triamcinolone ointment with no adverse effects. Doxycycline is proved to be one of the modalities for the treatment of aphthous ulcer.