Efficacy of Saccharomyces boulardii in treatment of candida esophagitis

Abstract

The efficacy and safety of Saccharomyces boulardii in treatment of candida esophagitis was investigated by a single center, prospective, open label and non-inferiority trial. Eighty nine patients with candida esophagitis attending in Shanxi Provincial People′s Hospital during April 2015 to March 2016 were randomly divided into Saccharomyces boulardii group (45 cases) and nystatin group (44 cases), and oral Saccharomyces boulardii powder and Nystatin tablets were given to two groups respectively. The curative effect was evaluated by gastroscopy after the treatment. The results showed that the cure rate of Saccharomyces boulardii group and nystatin group was 68.9%(31/45)and 63.6%(28/44), and the Saccharomyces boulardii was noi inferior to nystatin (χ2=3.027, P 0.05]. The incidence of adverse reactions in boulardii group was significantly lower than that in nystatin group [2.2%(1/45) vs. 22.7%(10/44), χ2=8.636, P<0.05]. The study suggests that the cure rate of Saccharomyces boulardii is not inferior to nystatin in treatment of candida esophagitis, while the incidence of adverse reactions of Saccharomyces boulardii is lower. Key words: Candida; Esophagitis; Saccharomyces; Nystatin