Efficacy of rosiglitazone combined with metformin on patients with non - alcoholic fatty live diseases

Abstract

Objective To study the efficacy of rosiglitazone combined with metformin on patients with non -alcoholic fatty liver diseases (NAFLD).Methods One hundred and twenty patients with non -alcoholic fatty liver disease were randomly divided into three groups:control group,rosiglitazone treatment group,and rosiglitazone combined with metformin treatment group,6 months were one cycle in all three groups.The evaluating indexes including body mass index( BMI),blood lipid,liver enzyme activities,fasting blood glucose ( FPG),fasting blood insulin ( FBI),insulin resistance index ( IRI),clinical symptoms,physical signs,and results of B - ultrasonic examination in liver.Results The patients treated with rosiglitazone or combined with metformin,levels of TC,TG,ALT,AST and IRI were obviously improved than those before treatment( P ＜ 0.05 ).The patients treated with rosightazone combined with metformin,levels of BMI were obviously improved than those before treatment( P ＜0.05).The total effective rates in these groups were significantly higher than that in control group( P ＜0.01 ).Conclusions The treatment of pioglitazone is safe and effective to NAFLD,and the therapeutic effect of combination use is superior to that of pioglitazone or metformin use alone. Key words: Rosiglitazone; Metformin; Non - alcoholic fatty live disease