Efficacy of repair and reconstruction therapy for the treatment of lateral ankle ligament injury: A protocol of systematic review and meta-analysis.

Abstract

In this study, we will explore the efficacy and safety of repair and reconstruction therapy (RRT) for patients with lateral ankle ligament injury (LALI). Searches will be carried out in the Medline, EMBASE, Web of Science, Cochrane Library, PsycINFO, China National Knowledge Infrastructure, along with a comprehensive search of grey literature. All databases will be searched from inception to the March 1, 2020 with no restrictions to language and publication status. Two investigators will independently conduct selection of study, information collection, and risk of bias assessment, respectively. A third investigator will help to solve any different opinions between 2 investigators. RevMan 5.3 software will be utilized for statistical analysis. This study will assess the efficacy and safety of RRT for patients with LALI through assessing pain intensity, ankle function after ligament injury, time to return to work, time to return to sports, Tegner activity level, quality of life, and adverse events. This study summarizes latest evidence of RRT for patients with LALI and may provide guidance for clinical practice.Study registration number: INPLASY202040082.