Abstract
AbstractSome protective-decontaminating ointments based on polyethylene glycol (PEG) of different molecular weights were tested per se and with the added active ingredient oxime N-octylpyridinium-4-aldoximebromide (OPAB) against percutaneous poisoning with a thickened formulation of the nerve gas soman, in rats after 60 min exposure. Ointments consisting of low-molecular-weight PEGs (O1) proved to be the most efficient regardless of oxime addition. In the combination of lower- and medium-molecular-weight PEGs (O2) or lower- and higher-molecular weight PEGs (O3), the addition of oxime significantly improved their effectiveness.
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