Abstract
Background: Among various types of headaches, Migraine is very common, universal, and disabling neurological disorder. The average prevalence of migraine is about 18% in women and 6% in men. This study was conducted to evaluate efficacy of propranolol plus flunarizine combination and valproate monotherapy in migraine prophylaxis in a tertiary care teaching hospital in Western Odisha. Materials & Methods: For the present study 58 adult and adolescent (age > 12 years) patients diagnosed with migraine were enrolled equally into 2 groups. Group I patients received Valproate 500 mg once daily dose and group II received Propranolol 40 mg plus Flunarizine 10 mg once daily dose. Parameters such as complete blood count, blood sugar, liver function test, urea, creatinine, sodium, potassium estimation, 12 lead ECG etc. was performed. MIDAS score was also recorded. Results: Group I had 19 males and 10 females and group II had 18 males and 11 females.
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