EFFICACY OF PROPHYLACTIC INTRAVENOUS ADMINISTRATION OF ONDANSETRON FOR PREVENTION OF SPINAL ANESTHESIA INDUCED HYPOTENSION IN ELDERLY PATIENTS

Abstract

Objective: Hypotension is the commonest side effect associated with spinal anesthesia. Multiple modalities have been tested to nd adequate preventive measure. Main objective of this study is to nd out the effectiveness of prophylactic administration of inj. ondansetron for prevention of spinal anesthesia induced hypotension in elderly patients.Study design: Double blind, randomized controlled trial. Place and duration of study: This study was conducted in our anesthesiology department from March 2020 to August 2020.Method: 100 patients were selected for the study using non-probability sampling technique, and divided into two groups of 50 each using random numbers table. Each patient was preloaded with ringer's lactate solution in a dose of 10 ml/kg. Patients of Group A received 8 mg of ondansetron IV ve minutes prior to administration of spinal anesthesia; whereas patients of Group B were injected normal saline IV. Data were collected and analyzed using IBM SPSS version 20. Chi square test was used to compare hypotension between two groups. A p-value < 0.05 was taken as signicant. Results: Mean age of Group A was 64.16 ± 8.47 years, whereas that of Group B was 62.58 ± 8.99 (p value=0.39). Mean weight of Group A was 72.64 ± 5.82 kg, whereas that of Group B was 70.66 ± 5.96 kg (p - value=0.295). Hypotension was present in 23 (46%) patients in Group A, where as it was present in 34 (68%) patients in Group B (p value= 0.026). Bradycardia was recorded in 3(06%) vs.11(22%) patients in Group A and B respectively (p=0.021). Conclusion: We conclude that intravenous administration of 8 mg of ondansetron, 5 minutes prior to subarachnoid block, is effective in decreasing frequency of hypotension and bradycardia in elderly patients.