Abstract
Introduction: Different pharmacological approach for preemptive analgesia have been tried with varying degree of success. Preemptive analgesia results in decrease in postoperative opioid requirement and hence decreases opioid related complication.
 Objectives: This study aims to evaluate pregabalin as preemptive analgesic in scheduled cases.
 Methodology: Fourty ASA I and II patients posted for elective laparoscopic cholecystectomy under general anesthesia were divided into two groups of twenty. Group A received pregabalin 300 mg, two hours before induction of anesthesia but group B were not given any medication. Postoperative VAS Score, Ramsay Sedation Score, postoperative nausea and vomiting and postoperative opioid requirement in two groups were observed over 48 hours and noted.Results: The mean VAS scores were higher in control group whereas the mean Ramsay score was higher in group pregabalin in the first six hours in the post operative period which was statistically significant. The mean Ramsay sedation score was same (2) in both the group after twelve post operative period. Postoperative nausea and vomiting was lower in the pregabalin group. Requirement of post operative analgesia was higher in the control group.
 Conclusion: Preemptive use of Pregabalindecreasespostoperateive pain, postoperative opioid requirement and increases postoperative sedation.
Highlights
The interna onal society for study of pain has defined pain as an unpleasant sensory and emo onal experience associated with actual or poten al ssue damage, or described in terms of such damage
Postopera ve nausea and vomi ng was lower in the pregabalin group
Since Pregabalin is known to inhibit the development of central sensi za on and a enuate postopera ve pain and decrease analgesic consump on, the present study was designed to evaluate the role of a preopera ve singleoraldoseofpregabalin(300mg)aspreemp veanalgesic
Summary
The interna onal society for study of pain has defined pain as an unpleasant sensory and emo onal experience associated with actual or poten al ssue damage, or described in terms of such damage. Pregabalin similar to gabapen n, binds to the a-2-dsubunit of voltage-gated calcium channels which results in reduc on of the release of excitatory neurotransmi ers and inhibit the development of central sensi za on. This property of pregabalin can be used preopera vely for preemp ve analgesia as well.[4] Pregabalin has been approved for the treatment of par al seizure, pain fuldiabe c neuropathy, post herpe c neuralgia and fibromyalgia. Since Pregabalin is known to inhibit the development of central sensi za on and a enuate postopera ve pain and decrease analgesic consump on, the present study was designed to evaluate the role of a preopera ve singleoraldoseofpregabalin(300mg)aspreemp veanalgesic
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