Abstract
We aimed to investigate the efficacy of preemptive analgesia of celecoxib on postoperative pain, patients’ global assessment (PGA) and hip function recovery compared to postoperative analgesia of celecoxib in femoroacetabular impingement (FAI) patients who underwent hip arthroscopy surgery (HAS). The 100 FAI patients underwent HAS were randomly allocated to preemptive analgesia group (N = 50) or postoperative analgesia group (N = 50) as a 1:1 ratio for 3 months. Pain visual analog scale (VAS) score, PGA score, rescue-use pethidine consumption and Harris hip score were assessed. Compared to postoperative analgesia group, pain VAS score decreased on day 1 (P = 0.036), day 2 (P = 0.046) and day 3 (P = 0.046), while was similar prior to operation (P = 0.587), on day 7 (P = 0.398), at month 1 (P = 0.461) and month 3 (P = 0.805) in preemptive analgesia group. Besides, rescue-use pethidine consumption was decreased in preemptive analgesia group than postoperative analgesia group within 3 days (P = 0.016) and within 7 days (P = 0.033) post-operation. For PGA score, it reduced on day 2 (P = 0.030) and day 3 (P = 0.048), while was similar prior to operation (P = 0.699), on day 1 (P = 0.699), day 7 (P = 0.224), at month 1 (P = 0.640) and month 3 (P = 0.400) in preemptive analgesia group than postoperative analgesia group. For Harris hip score, it was similar prior to operation (P = 0.372), on day 7 (P = 0.366), at month 1 (P = 0.466) and month 3 (P = 0.658) between the two groups. In conclusion, preemptive analgesia of celecoxib decreases short-term postoperative pain and PGA, but without effect on long-term hip function recovery than postoperative analgesia of celecoxib in FAI patients who underwent HAS.
Highlights
Femoroacetabular impingement (FAI) is a clinical syndrome characterized by the anatomic abnormalities of the femoral head and/or the acetabulum
There was no difference in FAI type (P = 0.673), pain visual analog scale (VAS) score (P = 0.587), patients’ global assessment (PGA) score (P = 0.674) or Harris hip score (P = 0.372) between the two groups
Investigating the optimum time for the use of celecoxib is necessary, which might have critical effects on improving postoperative pain management for FAI. We carried out this randomized controlled study to compare the efficacy of preemptive analgesia of celecoxib versus its postoperative use on pain management and PGA in FAI patients who underwent hip arthroscopy surgery (HAS), and we discovered that preemptive analgesia of celecoxib presented with better efficacy on decreasing short-term pain VAS score and short-term PGA score compared to postoperative analgesia of celecoxib in FAI patients who underwent HAS
Summary
Femoroacetabular impingement (FAI) is a clinical syndrome characterized by the anatomic abnormalities of the femoral head and/or the acetabulum. Exploring additional and convincing methods for pain management to decrease pain and promote disease recovery in FAI patients underwent HAS is essential. A few studies have shown that celecoxib has benefits on reducing pain and preventing heterotopic ossification formation in FAI patients who underwent HAS (Cogan et al 2016; Kahlenberg et al 2017). Whether there are differences between preemptive analgesia and postoperative analgesia of celecoxib in treating FAI patients who underwent HAS is still unclear. Exploration about the optimum dosage time of celecoxib is necessary to improve the pain management and function recovery. We performed this study and the purpose was to investigate the efficacy of preemptive analgesia of celecoxib on postoperative pain, patients’ global assessment (PGA) and hip function recovery compared to postoperative analgesia in FAI patients who underwent HAS
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