Efficacy of Pluronic F-127 gel containing green tea catechin extract on chronic periodontitis – A clinical study

Raghavendra Reddy Nagate,M Yuvaraja,Nabeeh A Alqahtani,K.S Ravi,Saad M Alqahtani,Shankar T Gokhale,Shreyas Tikare,Mohammed Fadul A Elagib

doi:10.4314/tjpr.v19i2.27

Raghavendra Reddy Nagate, M Yuvaraja + Show 6 more

Open Access

https://doi.org/10.4314/tjpr.v19i2.27

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Abstract

Purpose: To evaluate the efficacy of pluronic F-127 gel containing green tea catechin extract as a local drug delivery system in the treatment of chronic periodontitis. Methods: A total of 20 chronic periodontitis patients participated as per the set inclusion and exclusion criteria. Complete scaling and root planing (SRP) was done for all subjects and pluronic F-127 gel containing green tea catechin was applied on one site. The contralateral site received SRP alone. The plaque index (PI), gingival index (GI), and probing pocket depth (PPD) were recorded at baseline and on the 28th day. Results: At the 28th-day follow-up, green tea catechin tooth sites showed significantly lower mean scores (GI = 0.55, p = 0.30 and PPD = 3.35 mm) than the corresponding SRP tooth sites (GI = 1.25, PI = 1.15, and PPD = 4.40 mm) (p < 0.05). Conclusion: When compared to scaling and root planing alone, the local drug delivery gel containing green tea catechin as an adjuvant was more effective in reducing the clinical parameters of periodontitis. Keywords: Adjuvant therapy, Camellia sinensis, Local drug delivery, Periodontal pocket

Highlights

Chronic periodontitis is one of the most common oral health conditions
The management of chronic periodontitis such as scaling and root planing and surgical therapies are aimed at eliminating the sub-gingival microflora responsible for local bacterial infection [2]
The objective of this study was to evaluate the efficacy of Pluronic F-127 (PF-127) gel containing green tea catechin extract in the treatment of chronic periodontitis

Summary

Introduction

The management of chronic periodontitis such as scaling and root planing and surgical therapies are aimed at eliminating the sub-gingival microflora responsible for local bacterial infection [2]. Complete bacterial elimination from periodontal pockets is often difficult due to the indigenous nature of the sub-gingival microflora, the chances of repopulation after periodontal therapy is high [3]. -©---2-0--2--0--T--h--e--a--u-t-h--o--r-s-.--T--h-i-s--w---o-r-k---is---li-c-e--n--s-e--d--u--n--d-e--r--t-h-e---C--r-e--a-t-i-v-e---C--o--m--Tm--r-oo-n-p-s-J--AP-t-th-r-ai-b-ru-m-t-i-oR-n-e--4s-,.-0-F--eI-nb-t-re-u-r-na--ar-yt-i-o2-n-0-a-2-l0-L-;-ic-1-e-9-n(-2s--e)-:--4--2-7 periodontal pathogens, as an adjunct to mechanical therapy, has been recommended [4]. Drug concentrations in the gingival crevicular fluid through systemic anti-microbial therapy do not attain the minimum inhibitory concentration (MIC) against the pathogenic microorganisms for a sustained period [5]. Several local drug delivery (LDD) systems containing anti-microbial agents have been introduced as adjunct to mechanical therapies for overcoming this limitation

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