Abstract
BackgroundOsteoarthritis (OA) is a degenerative disease commonly affecting the knee joints. It affects patients socially, psychologically and economically and rates of the disease have been increasing due to obesity and old age. Regardless of choosing a medically conservative approach, it is a challenge in the long term to provide OA patients efficient treatment with minimal side effects and long-term efficiency. Platelet-rich plasma (PRP) is a convenient, low-cost and affordable treatment technique used in treating knee OA with encouraging efficient and safe outcomes. In this study we will investigate the effect of PRP on knee OA.MethodsThis is a prospective cohort study involving 252 patients with different OA grades. The Kellgren and Lawrence (K&L) system was used in classifying the affected knee by degenerative cartilage lesions as well as early and severe OA. All patients with a diagnosis of knee OA were screened in every visit before the injection, the pain was assessed by the 0-10 Numeric Rating Scale (NRS), and knee range of motion including flexion and extension was assessed by goniometer. Follow-up appointments were done on three-month intervals for a total of three visits for evaluation. Injection of PRP was given to all the patients with a maximum of four injections. The results were evaluated statistically according to the total number of follow-up visits.ResultsIn grade II patients, the pain improved with the visits and the maximum improvement in flexion degree was noticed in patients who came for a total of three follow-up visits. In grade III patients, the most improvement in pain was in patients who came for three follow-up visits, while the most improvement in flexion degree was in patients who came for a total of two follow-up visits. Patients with grade IV who came for three follow-up visits showed the most improvement in pain and degree of flexion.ConclusionsIntra-articular injections gave significant pain and flexion improvement in grades II, III and IV in OA patients, especially with multiple injection in the short-term follow-up. As a result, recommendation of repeated multiple injections up to four times is efficient in providing long time relief in knee OA.
Highlights
Osteoarthritis (OA) is the most common type of arthritis and degenerative disease affecting around 250 million globally [1]
All patients with a diagnosis of knee OA were screened in every visit before the injection, the pain was assessed by the 0-10 Numeric Rating Scale (NRS), and knee range of motion including flexion and extension was assessed by goniometer
In grade II patients, the pain improved with the visits and the maximum improvement in flexion degree was noticed in patients who came for a total of three follow-up visits
Summary
Osteoarthritis (OA) is the most common type of arthritis and degenerative disease affecting around 250 million globally [1] It affects patients socially, psychologically and economically and rates of the disease have been increasing due to obesity and old age [1,2,3]. In addition to aging and obesity, several risk factors for OA include gender, genetics, smoking and previous joint injury [1] Other illnesses such as rheumatoid arthritis and metabolic disorders can decrease bone density, increasing the susceptibility to develop OA [3]. Osteoarthritis (OA) is a degenerative disease commonly affecting the knee joints It affects patients socially, psychologically and economically and rates of the disease have been increasing due to obesity and old age. In this study we will investigate the effect of PRP on knee OA
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