Efficacy of physalis peruviana on restoring histopathological alternations against lead induced toxicity in albino rats

Abstract

<h2>Summary</h2><h3>Background</h3> Lead is a highly persistent element threatening humanity. <h3>Objective</h3> The study aims to evaluate the efficacy of <i>Physalis Peruviana</i> fruit extract (P.P) in restoring the histological deformation of liver and kidney in lead-poisoned rats. <h3>Methodology</h3> Experimental study was conducted on seventy-two male albino rats. The study was implemented in two phases, 1^st phase (induction period). Second phase concerned with treatment using different concentrations of <i>Physalis Peruviana</i> fruit extract. Rats classified into control, control positive (without treatment), group III (200μg/g), IV (300 μg/g), V (500 μg/g), and VI (300 μg/g P.P for 56 day throughout the two phase). <h3>Results</h3> Histopathological examination showed hepatocytes appeared typically polygonal with distinct cell margin and renal tubules appeared highly injured and degeneration occurred in groups III, IV, and V after 8 weeks in a dose-dependent manner, while group VI treated with 300 P.P parallel with intoxication phase revealed minimal morphological changes except in few areas around the central vein after 4 weeks and exhibited a marked degree of recovery in kidney tubules compared to control positive group. Otherwise, after 8 weeks, hepatocyte and kidney tissues showed more or less typical architecture, as compared to the control group. However, a slight deterioration indicated the protective role of PP consumption. <h3>Conclusions</h3> The consumption of <i>Physalis Peruana</i> fruit in daily life restores almost all abnormalities that occurred within the tissues of the liver and kidneys as a result of lead poisoning and helps to improve the typical structure and thus improve the quality of human health.